Article
Stemness of B-cell progenitors in multiple myeloma bone marrow.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2012
Boucher Kelly, Parquet Nancy, Widen Raymond, Shain Kenneth, Baz Rachid, Alsina Melissa, Koomen John, Anasetti Claudio, Dalton William, Perez Lia E
Abstract excerpt
PURPOSE: In myeloma, B cells and plasma cells show a clonal relationship. Clonotypic B cells may represent a tumor-initiating compartment or cancer stem cell responsible for minimal residual disease in myeloma. EXPERIMENTAL DESIGN: We report a study of 58 patients with myeloma at time of diagnosis or relapse. B cells in bone marrow were evaluated by multicolor flow cytometry and sorting. Clonality was determined...
Topics
- Antigens, CD
- Antineoplastic Agents, Alkylating
- Apoptosis
- Bone Marrow
- Bone Marrow Cells
- Cell Separation
- Cells, Cultured
- Culture Media, Conditioned
- Flow Cytometry
- Hematopoietic Stem Cells
- Humans
- Melphalan
- Multiple Myeloma