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Article

Characterization of clonogenic multiple myeloma cells

25 Nov 2003

Abstract excerpt

The identity of the cells responsible for the initiation and maintenance of multiple myeloma (MM) remains unclear largely because of the difficulty growing MM cells in vitro and in vivo. MM cell lines and clinical specimens are characterized by malignant plasma cells that express the cell surface antigen syndecan-1 (CD138); however, CD138 expression is limited to terminally differentiated plasma cells during...

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PMID: 14630803
DOI: 10.1182/blood-2003-09-3064

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