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Article

Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus.

Genesis (New York, N.Y. : 2000) - 1 Mar 2005

Bunger Maureen K, Walisser Jacqueline A, Sullivan Ruth, Manley Paul A, Moran Susan M, Kalscheur Vicki L, Colman Ricki J, Bradfield Christopher A

Abstract excerpt

Disruption of the murine Mop3 (also known as Bmal1 or Arntl) locus results in a loss of behavioral and molecular circadian rhythms. Although Mop3 null mice do not display anomalies in early development, they do display reduced activity as they age. In an effort to explain this decreased activity, we characterized the physiological and anatomical changes that occurred with age. We observed that Mop3 null mice...

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PMID: 15739187
DOI: 10.1002/gene.20102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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