Article
Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse.
The Journal of heredity - 1 Jan 2000
Marks S C, Lane P W
Abstract excerpt
Osteopetrosis (op/op) is a new mutation in the mouse that is transmitted as an autosomal recessive linked with variant waddler (Va) on chromosome 12. Compared with normal littermates, young op/op mice have excessive accumulations of bone without marrow cavities, increases in bone matrix formation and concentrations of parafollicular cells of the thyroid, and are hypophosphatemic. Osteoclasts from op/op mice are...
Topics
- Animals
- Body Weight
- Chromosome Mapping
- Chromosomes
- Disease Models, Animal
- Genes
- Genes, Recessive
- Genetic Linkage
- Mice
- Mutation
- Osteopetrosis
- Skull