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Article

BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3

21 Dec 2017

Abstract excerpt

Skeletal mandibular hypoplasia (SMH), one of the common types of craniofacial deformities, seriously affects appearance, chewing, pronunciation, and breathing. Moreover, SMH is prone to inducing obstructive sleep apnea syndrome. We found that brain and muscle ARNT-like 1 (BMAL1), the core component of the molecular circadian oscillator, was significantly decreased in mandibles of juvenile SMH patients....

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PMID: 29276151
DOI: 10.1016/j.stemcr.2017.11.017

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