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Article

The Sept4 septin locus is required for sperm terminal differentiation in mice.

Developmental cell - 1 Mar 2005

Kissel Holger, Georgescu Maria-Magdalena, Larisch Sarit, Manova Katia, Hunnicutt Gary R, Steller Hermann

Abstract excerpt

The murine septin4 gene (Sept4) has been implicated in diverse cellular functions, including cytokinesis, apoptosis, and tumor suppression. Here, we investigated the function of Sept4 proteins during mouse development by creating a targeted deletion of the Sept4 genomic locus. Sept4 mutant mice are viable but male sterile due to immotile and structurally defective sperm. During spermatogenesis, Sept4 proteins...

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Source

Identifiers

PMID: 15737931
DOI: 10.1016/j.devcel.2005.01.021

Genes

XIAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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