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Article

The role of the septin family in spermiogenesis

1 Oct 2011

Abstract excerpt

SEPTINS (FULL NAME: Septin; symbol name: SEPT) belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, including membrane compartmentalization, vesicle trafficking, mitosis and cytoskeletal remodeling. Two of the 14 family members in the mammalian species, Septin12 and 14 are expressed specifically in the testis. In the mouse, knockout of Septin4 and Septin12 leads...

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PMID: 22332113
DOI: 10.4161/spmg.1.4.18326

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The role of the septin family in spermiogenesisPMID 22332113Read ↗

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Biallelic loss‐of‐function mutations in SEPTIN4 ( C17ORF47 ), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humansSemantic proximity Read ↗

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