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Article

The SEPT12 complex is required for the establishment of a functional sperm head-tail junction.

Molecular human reproduction - 1 Jun 2020

Shen Yi-Ru, Wang Han-Yu, Tsai Yung-Chieh, Kuo Yung-Che, Wu Shang-Rung, Wang Chia-Yih, Kuo Pao-Lin

Abstract excerpt

The connecting pieces of the sperm neck link the flagellum and the sperm head, and they are important for initiating flagellar beating. The connecting pieces are important building blocks for the sperm neck; however, the mechanism of connecting piece assembly is poorly understood. In the present study, we explored the role of septins in sperm motility and found that Sept12D197N knock-in (KI) mice produce...

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PMID: 32392324
DOI: 10.1093/molehr/gaaa031

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