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Article

SEPTIN12 genetic variants confer susceptibility to teratozoospermia.

PloS one - 1 Jan 2012

Lin Ying-Hung, Wang Ya-Yun, Chen Hau-Inh, Kuo Yung-Che, Chiou Yu-Wei, Lin Hsi-Hui, Wu Ching-Ming, Hsu Chao-Chin, Chiang Han-Sun, Kuo Pao-Lin

Abstract excerpt

It is estimated that 10-15% of couples are infertile and male factors account for about half of these cases. With the advent of intracytoplasmic sperm injection (ICSI), many infertile men have been able to father offspring. However, teratozoospermia still remains a big challenge to tackle. Septins belong to a family of cytoskeletal proteins with GTPase activity and are involved in various biological processes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22479503
DOI: 10.1371/journal.pone.0034011
PMCID: PMC3316533

Genes

SEPTIN12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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SEPTIN12 genetic variants confer susceptibility to teratozoospermia.PMID 22479503Read ↗

Single-nucleotide polymorphism c.474G>A in the SEPT12 gene is a predisposing factor in male infertility.Semantic proximity Read ↗

SEPTIN12 c.474 G > A polymorphism as a risk factor in teratozoospermic patients.Semantic proximity Read ↗

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<i>SEPT12</i>mutations cause male infertility with defective sperm annulusSemantic proximity Read ↗

The expression level of septin12 is critical for spermiogenesis.Semantic proximity Read ↗

SEPT14 Mutations and Teratozoospermia: Genetic Effects on Sperm Head Morphology and DNA IntegritySemantic proximity Read ↗

SEPT14 complexes maintain sperm morphogenesis and functionSemantic proximity Read ↗

Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome.Semantic proximity Read ↗

Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization FailureSemantic proximity Read ↗

SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis.Semantic proximity Read ↗

Biallelic loss‐of‐function mutations in SEPTIN4 ( C17ORF47 ), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humansSemantic proximity Read ↗

A novel homozygous mutation in DNAJB13-a gene associated with the sperm axoneme-leads to teratozoospermia.Semantic proximity Read ↗

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