Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis.

International journal of molecular sciences - 16 Nov 2016

Lai Tsung-Hsuan, Wu Ying-Yu, Wang Ya-Yun, Chen Mei-Feng, Wang Pei, Chen Tsung-Ming, Wu Yi-No, Chiang Han-Sun, Kuo Pao-Lin, Lin Ying-Hung

Abstract excerpt

Male factor infertility accounts for approximately 50 percent of infertile couples. The male factor-related causes of intracytoplasmic sperm injection failure include the absence of sperm, immotile sperm, immature sperm, abnormally structured sperm, and sperm with nuclear damage. Our knockout and knock-in mice models demonstrated that SEPTIN12 (SEPT12) is vital for the formation of sperm morphological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Infertility, Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Pore Complex Proteins

Share to Nucleoproteins

Share to Septins

Share to Spermatogenesis

Share to Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 27854341
DOI: 10.3390/ijms17111911
PMCID: PMC5133908

Genes

NDC1
SEPTIN12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis.PMID 27854341Read ↗

The role of the septin family in spermiogenesisSemantic proximity Read ↗

SEPT14 complexes maintain sperm morphogenesis and functionSemantic proximity Read ↗

The expression level of septin12 is critical for spermiogenesis.Semantic proximity Read ↗

SEPT12/SPAG4/LAMINB1 Complexes Are Required for Maintaining the Integrity of the Nuclear Envelope in Postmeiotic Male Germ CellsSemantic proximity Read ↗

The SEPT12 complex is required for the establishment of a functional sperm head-tail junction.Semantic proximity Read ↗

SEPTIN12 genetic variants confer susceptibility to teratozoospermia.Semantic proximity Read ↗

Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization FailureSemantic proximity Read ↗

Biallelic loss‐of‐function mutations in SEPTIN4 ( C17ORF47 ), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humansSemantic proximity Read ↗

SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junctionSemantic proximity Read ↗

<i>SEPT12</i>mutations cause male infertility with defective sperm annulusSemantic proximity Read ↗

The Sept4 septin locus is required for sperm terminal differentiation in mice.Semantic proximity Read ↗

Septins at the annulus of mammalian spermSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.