Article
The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan.
Anticancer research - 1 Jan 2000
Lin Wei-Yu, Chou Yu-Ching, Wu Mei-Hsuan, Huang Han-Bin, Jeng Yi-Lin, Wu Cho-Chieh, Yu Cheng-Pung, Yu Jyh-Cherng, You San-Lin, Chu Tang-Yuan, Chen Chien-Jen, Sun Chien-An
Abstract excerpt
BACKGROUND: We evaluated the effects of the MTHFR C677T polymorphism and its interaction with estrogen exposure on breast cancer risk in a nested case-control study conducted in Taiwan. MATERIALS AND METHODS: A total of 88 histologically confirmed breast cancer cases and 344 cancer-free controls were recruited between July 1992 and December 2000. The MTHFR C677T genotype was determined by a PCR-RFLP-based assay....
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