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Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls.

Breast cancer research and treatment - 1 Sept 2010

Qi Xiaowei, Ma Xiangyu, Yang Xinhua, Fan Linjun, Zhang Yi, Zhang Fan, Chen Li, Zhou Yan, Jiang Jun

Abstract excerpt

The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast cancer risk has been widely reported, but results were inconsistent and underpowered. To clarify the effects of MTHFR polymorphisms on the risk of breast cancer, an updated meta-analysis of all available studies relating C677T and/or A1298C polymorphisms of MTHFR gene to the risk of breast cancer was conducted....

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Source

Identifiers

PMID: 20135343
DOI: 10.1007/s10549-010-0773-7

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls.PMID 20135343Read ↗

Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibilitySemantic proximity Read ↗

A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in breast cancer.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations.Semantic proximity Read ↗

MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis.Semantic proximity Read ↗

The association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population.Semantic proximity Read ↗

ASSOCIATION OF MTHFR A1298C POLYMORPHISM WITH BREAST CANCER AND/OR OVARIAN CANCER RISK: AN UPDATED META-ANALYSIS.Semantic proximity Read ↗

Association of C677T (rs1081133) and A1298C (rs1801131) Methylenetetrahydrofolate Reductase Variants with Breast Cancer Susceptibility Among Asians: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility: a meta-analysis based on 38 case-control studies with 40,985 subjects.Semantic proximity Read ↗

Association between the MTHFR C677T Polymorphism and Breast Cancer Risk: A Meta-Analysis of 23 Case-Control Studies.Semantic proximity Read ↗

[Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer].Semantic proximity Read ↗

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