Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis.

doi:10.1007/s10549-006-9491-6

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Article

Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis.

Breast cancer research and treatment - 1 Dec 2007

Macis Debora, Maisonneuve Patrick, Johansson Harriet, Bonanni Bernardo, Botteri Edoardo, Iodice Simona, Santillo Barbara, Penco Silvana, Gucciardo Giacomo, D'Aiuto Giuseppe, Rosselli Del Turco Marco, Amadori Marinella, Costa Alberto, Decensi Andrea

Abstract excerpt

BACKGROUND: A reduced activity of methylenetetrahydrofolate reductase (MTHFR) due to frequent C677T polymorphism affects DNA synthesis, repair and methylation and may be implicated in breast cancer risk. METHODS: We conducted a nested case-control study within a phase III prevention trial of tamo...

Topics

Aged
Aged, 80 and over
Breast Neoplasms
Case-Control Studies
Clinical Trials, Phase III as Topic
Female
Genetic Predisposition to Disease
Genotype
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Multicenter Studies as Topic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Polymorphism, Genetic

Randomized Controlled Trials as Topic

Selective Estrogen Receptor Modulators

Tamoxifen

Source

Open in PubMed

Identifiers

PMID: 17260091
DOI: 10.1007/s10549-006-9491-6

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17260091-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.