Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis.

Breast cancer research and treatment - 1 Dec 2007

Macis Debora, Maisonneuve Patrick, Johansson Harriet, Bonanni Bernardo, Botteri Edoardo, Iodice Simona, Santillo Barbara, Penco Silvana, Gucciardo Giacomo, D'Aiuto Giuseppe, Rosselli Del Turco Marco, Amadori Marinella, Costa Alberto, Decensi Andrea

Abstract excerpt

BACKGROUND: A reduced activity of methylenetetrahydrofolate reductase (MTHFR) due to frequent C677T polymorphism affects DNA synthesis, repair and methylation and may be implicated in breast cancer risk. METHODS: We conducted a nested case-control study within a phase III prevention trial of tamoxifen. After a median follow-up of 81.2 months, 79 of the 5,408 hysterectomised women aged 35-70 years, who had...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Case-Control Studies

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Neoplasm Staging

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 17260091
DOI: 10.1007/s10549-006-9491-6

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis.PMID 17260091Read ↗

Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies.Semantic proximity Read ↗

The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan.Semantic proximity Read ↗

A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in breast cancer.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibilitySemantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Moroccan women.Semantic proximity Read ↗

Association between the MTHFR C677T Polymorphism and Breast Cancer Risk: A Meta-Analysis of 23 Case-Control Studies.Semantic proximity Read ↗

MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.Semantic proximity Read ↗

The association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population.Semantic proximity Read ↗

Polymorphisms in the MTHFR gene are associated with breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.