Article
Evaluation of the contribution of methylenetetrahydrofolate reductase genotypes to Taiwan breast cancer.
Anticancer research - 1 Aug 2014
Huang Chung-Yu, Chang Wen-Shin, Shui Hao-Ai, Hsieh Yung-Hung, Loh Ching-Hui, Wang Hwei-Chung, Ji Hong-Xue, Hsiao Chieh-Lun, Hsu Chin-Mu, Tsai Chia-Wen, Bau Da-Tian
Abstract excerpt
The aim of the present study was to evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and its interaction with early-onset breast cancer risk in Taiwan. Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed and their joint effects with individual age- and estrogen-related factors on breast cancer risk were discussed....
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