Article
Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2009
Platek Mary E, Shields Peter G, Marian Catalin, McCann Susan E, Bonner Matthew R, Nie Jing, Ambrosone Christine B, Millen Amy E, Ochs-Balcom Heather M, Quick Sylvia K, Trevisan Maurizio, Russell Marcia, Nochajski Thomas H, Edge Stephen B, Freudenheim Jo L
Abstract excerpt
It has been hypothesized that effects of alcohol consumption on one-carbon metabolism may explain, in part, the association of alcohol consumption with breast cancer risk. The methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) genes express key enzymes in this pathway. We investigated the association of polymorphisms in MTHFR (rs1801133 and rs1801131) and...
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