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Article

Are neuronal SNARE proteins Ca2+ sensors?

Journal of molecular biology - 18 Mar 2005

Chen Xiaocheng, Tang Jiong, Sudhof Thomas C, Rizo Josep

Abstract excerpt

The neuronal SNARE complex formed by synaptobrevin, syntaxin and SNAP-25 plays a central role in Ca2+-triggered neurotransmitter release. The SNARE complex contains several potential Ca2+-binding sites on the surface, suggesting that the SNAREs may be involved directly in Ca2+-binding during release. Indeed, overexpression of SNAP-25 bearing mutations in two putative Ca2+ ligands (E170A/Q177A) causes a decrease...

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Identifiers

PMID: 15733924
DOI: 10.1016/j.jmb.2005.01.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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