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Article

Factor XI promotes hemostasis in factor IX-deficient mice.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2018

Mohammed B M, Cheng Q, Matafonov A, Monroe D M, Meijers J C M, Gailani D

Abstract excerpt

Essentials Mice lacking factor IX (FIX) or factor XI (FXI) were tested in a saphenous vein bleeding model. FIX-deficient mice displayed a hemostatic defect and FXI-deficient mice were similar to wild type mice. Infusion of FXI or over-expression of FXI in FIX-deficient mice improved hemostasis. FXI may affect the phenotype of FIX-deficiency (hemophilia B). SUMMARY: Background In humans, deficiency of coagulation...

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Identifiers

PMID: 30007049
DOI: 10.1111/jth.14243
PMCID: PMC6173617

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