Article
Genetics of lupus nephritis.
Lupus - 1 Jan 2005
Lauwerys B R, Wakeland E K
Abstract excerpt
Susceptibility to lupus nephritis is the end-result of complex interactions between polymorphic genetic factors involved in the regulation of immune responses. In humans, genome-wide screens and candidate-gene analyses led to the identification of several loci containing potential targets (FcgammaRIIa, PTPN22, PD-1, IL-10) for physiopathological research and therapeutic interventions. In mice, the generation of...
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