Article
The genetics of systemic lupus erythematosus.
Scandinavian journal of immunology - 1 Dec 1999
Lindqvist A K, Alarcón-Riquelme M E
Abstract excerpt
There is considerable evidence that the development of systemic lupus erythematosus (SLE) has a strong genetic basis. For more than 20 years, much effort has been made to understand the genetics of SLE. Association studies in humans suggest the existence of genetic effects by the alleles encoded in the HLA, deficiencies in the complement genes and the low-affinity variants of Fcgamma-receptors. In mouse models of...
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