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Article

Shear stress-initiated signaling and its regulation of endothelial function.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2014

Zhou Jing, Li Yi-Shuan, Chien Shu

Abstract excerpt

Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where blood flow pattern is disturbed rather than being laminar, and wall shear stress has an irregular distribution without defined directions. The endothelium in the atherosusceptible regions, in comparison to that in atheroresistant regions, shows activation of proproliferative and proinflammatory gene expressions, reduced...

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Topics

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Share to Atherosclerosis
Share to Endothelial Cells
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Hemodynamics

Share to Mechanotransduction, Cellular

Share to Regional Blood Flow

Share to Stress, Mechanical

Source

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Identifiers

PMID: 24876354
DOI: 10.1161/ATVBAHA.114.303422
PMCID: PMC4169328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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