Article
Identification of hypertension-related genes through an integrated genomic-transcriptomic approach.
Circulation research - 1 Apr 2005
Yagil Chana, Hubner Norbert, Monti Jan, Schulz Herbert, Sapojnikov Marina, Luft Friedrich C, Ganten Detlev, Yagil Yoram
Abstract excerpt
In search for the genetic basis of hypertension, we applied an integrated genomic-transcriptomic approach to identify genes involved in the pathogenesis of hypertension in the Sabra rat model of salt-susceptibility. In the genomic arm of the project, we previously detected in male rats two salt-susceptibility QTLs on chromosome 1, SS1a (D1Mgh2-D1Mit11; span 43.1 cM) and SS1b (D1Mit11-D1Mit4; span 18 cM). In the...
Topics
- Algorithms
- Animals
- Antigens, Differentiation
- Chromosome Mapping
- Desoxycorticosterone
- Drug Implants
- Dyneins
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Genomics