Article
Susceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure.
BMC genomics - 18 Jun 2024
Qi Han, Xie Yun-Yi, Yang Xiao-Jun, Xia Juan, Liu Kuo, Zhang Feng-Xu, Peng Wen-Juan, Wen Fu-Yuan, Li Bing-Xiao, Zhang Bo-Wen, Yao Xin-Yue, Li Bo-Ya, Meng Hong-Dao, Shi Zu-Min, Wang Yang, Zhang Ling
Abstract excerpt
BACKGROUND: Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, and it is difficult to precisely diagnose SSBP in population. So, we aimed to identify genes related to susceptibility to the SSBP, construct a risk evaluation model, and explore the potential...
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