Article
The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia.
Blood - 15 Feb 2004
Cook Mark A, Milligan Donald W, Fegan Christopher D, Darbyshire Philip J, Mahendra Premini, Craddock Charles F, Moss Paul A H, Briggs David C
Abstract excerpt
Killer immunoglobulin-like receptors (KIRs) regulate cell activity of natural killer (NK) cells and some T cells. The predominant ligand for inhibitory KIRs is HLA-C, which subdivides into 2 groups based on the specificity of inhibitory KIRs. The ligands for activatory KIRs are unknown. Following hematopoietic stem cell transplantation (HSCT), recipient tissues may not express a ligand for KIRs present within the...
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