Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

Blood - 15 Jun 2005

Petlickovski Aleksandar, Laurenti Luca, Li Xiaoping, Marietti Sara, Chiusolo Patrizia, Sica Simona, Leone Giuseppe, Efremov Dimitar G

Abstract excerpt

The clinical course of chronic lymphocytic leukemia (CLL) differs significantly between patients with mutated (M-CLL) and unmutated (U-CLL) immunoglobulin (Ig) variable heavy-chain (V(H)) genes, implying a role for B-cell receptor (BCR) signaling in the pathogenesis of this disease. We have now investigated activation of downstream BCR signaling pathways in U-CLL and M-CLL B cells using soluble anti-IgM (sol-IgM)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Signal-Regulated MAP Kinases
Share to Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin M

Share to JNK Mitogen-Activated Protein Kinases

Share to MAP Kinase Kinase 4

Share to Mitogen-Activated Protein Kinase Kinases

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 15728130
DOI: 10.1182/blood-2004-07-2669

Genes

BCR
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.PMID 15728130Read ↗

B-cell receptor signaling in chronic lymphocytic leukemiaSemantic proximity Read ↗

BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells.Semantic proximity Read ↗

Heterogeneous functional effects of concomitant B cell receptor and TLR stimulation in chronic lymphocytic leukemia with mutated versus unmutated Ig genes.Semantic proximity Read ↗

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia.Semantic proximity Read ↗

Signaling pathways activated by the B-cell receptor in chronic lymphocytic leukemiaSemantic proximity Read ↗

IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells.Semantic proximity Read ↗

B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia.Semantic proximity Read ↗

Targeting the B-cell receptor signaling pathway in B lymphoid malignanciesSemantic proximity Read ↗

Survival Response to B-Cell Receptor Ligation Is Restricted to Progressive Chronic Lymphocytic Leukemia Cells Irrespective of Zap70 ExpressionSemantic proximity Read ↗

Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

IL-4 rescues surface IgM expression in chronic lymphocytic leukemiaSemantic proximity Read ↗

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.