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Article

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia.

Blood - 1 Feb 2003

Lanham Stuart, Hamblin Terry, Oscier David, Ibbotson Rachel, Stevenson Freda, Packham Graham

Abstract excerpt

The mutational status of tumor immunoglobulin V(H) genes is providing a powerful prognostic marker for chronic lymphocytic leukemia (CLL), with patients having tumors expressing unmutated V(H) genes being in a less favorable subset. However, the biologic differences correlating with V(H) gene sta...

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Source

Identifiers

PMID: 12393552
DOI: 10.1182/blood-2002-06-1822

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12393552-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia.PMID 12393552Read ↗

BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells.Semantic proximity Read ↗

Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia.Semantic proximity Read ↗

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.Semantic proximity Read ↗

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profilingSemantic proximity Read ↗

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.Semantic proximity Read ↗

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status.Semantic proximity Read ↗

B-cell receptor signaling in chronic lymphocytic leukemiaSemantic proximity Read ↗

The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression.Semantic proximity Read ↗

CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.Semantic proximity Read ↗

Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia.Semantic proximity Read ↗

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.Semantic proximity Read ↗

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