Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia.

Blood - 1 Feb 2003

Lanham Stuart, Hamblin Terry, Oscier David, Ibbotson Rachel, Stevenson Freda, Packham Graham

Abstract excerpt

The mutational status of tumor immunoglobulin V(H) genes is providing a powerful prognostic marker for chronic lymphocytic leukemia (CLL), with patients having tumors expressing unmutated V(H) genes being in a less favorable subset. However, the biologic differences correlating with V(H) gene status that could determine the clinical course of the disease are unknown. Here we show that differing responses to IgM...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-ribosyl Cyclase
Share to ADP-ribosyl Cyclase 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Precursors

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin M

Share to Immunoglobulin Variable Region

Share to Receptors, Antigen, B-Cell

Share to Syk Kinase

Source

Identifiers

PMID: 12393552
DOI: 10.1182/blood-2002-06-1822

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia.PMID 12393552Read ↗

BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells.Semantic proximity Read ↗

Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia.Semantic proximity Read ↗

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.Semantic proximity Read ↗

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profilingSemantic proximity Read ↗

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.Semantic proximity Read ↗

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status.Semantic proximity Read ↗

B-cell receptor signaling in chronic lymphocytic leukemiaSemantic proximity Read ↗

The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression.Semantic proximity Read ↗

CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.Semantic proximity Read ↗

Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia.Semantic proximity Read ↗

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.