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Article

Heterogeneous functional effects of concomitant B cell receptor and TLR stimulation in chronic lymphocytic leukemia with mutated versus unmutated Ig genes.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2014

Chatzouli Maria, Ntoufa Stavroula, Papakonstantinou Nikos, Chartomatsidou Elisavet, Anagnostopoulos Achilles, Kollia Panagoula, Ghia Paolo, Muzio Marta, Stamatopoulos Kostas, Belessi Chrysoula

Abstract excerpt

We recently reported that chronic lymphocytic leukemia (CLL) subgroups with distinct clonotypic BCRs present discrete patterns of TLR expression, function, and/or tolerance. In this study, to explore whether specific types of BCR/TLR collaboration exist in CLL, we studied the effect of single versus concomitant BCR and/or TLR stimulation on CLL cells from mutated (M-CLL) and unmutated CLL (U-CLL) cases. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24719462
DOI: 10.4049/jimmunol.1302102

Genes

BCR
TLR7
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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