Article
IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells.
Leukemia - 1 May 2011
Coscia M, Pantaleoni F, Riganti C, Vitale C, Rigoni M, Peola S, Castella B, Foglietta M, Griggio V, Drandi D, Ladetto M, Bosia A, Boccadoro M, Massaia M
Abstract excerpt
Tumor cells in chronic lymphocytic leukemia (CLL) are more prone to apoptosis when cultured ex vivo, because they lack prosurvival signals furnished in vivo via B-cell receptor (BCR)-dependent and -independent pathways. This study compared the susceptibility of unmutated (UM) and mutated (M) CLL B cells to spontaneous apoptosis and prosurvival signals. UM CLL B cells showed a significantly higher rate of...
Topics
- Adult
- Aged
- Aged, 80 and over
- Apoptosis
- B-Lymphocytes
- Blotting, Western
- CD40 Ligand
- Electrophoretic Mobility Shift Assay
- Female
- Humans
- Immunoglobulin Heavy Chains