Article
Tumor necrosis factor-alpha -308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans.
Journal of autoimmunity - 1 Feb 2005
Rodríguez-Carreón Alma Angelica, Zúñiga Joaquín, Hernández-Pacheco Guadalupe, Rodríguez-Pérez José Manuel, Pérez-Hernández Nonanzit, Montes de Oca Jose Vicente, Cardiel Mario H, Granados Julio, Vargas-Alarcón Gilberto
Abstract excerpt
The aim of this study was to determine the frequency and potential relevance of the promoter polymorphisms of the tumor necrosis factor-alpha (TNF-alpha) in the severity of rheumatoid arthritis (RA) in Mexicans. HLA-DR and polymorphisms at positions -238 and -308 of TNF-alpha gene were determined in 137 Mexican RA patients (44 with severe and 93 with non-severe RA) as well as in 169 healthy controls (99 were...
Topics
- Alleles
- Arthritis, Rheumatoid
- Female
- Genotype
- HLA Antigens
- Humans
- Male
- Mexican Americans
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Tumor Necrosis Factor-alpha