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Article

Tumor necrosis factor-alpha -308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans.

Journal of autoimmunity - 1 Feb 2005

Rodríguez-Carreón Alma Angelica, Zúñiga Joaquín, Hernández-Pacheco Guadalupe, Rodríguez-Pérez José Manuel, Pérez-Hernández Nonanzit, Montes de Oca Jose Vicente, Cardiel Mario H, Granados Julio, Vargas-Alarcón Gilberto

Abstract excerpt

The aim of this study was to determine the frequency and potential relevance of the promoter polymorphisms of the tumor necrosis factor-alpha (TNF-alpha) in the severity of rheumatoid arthritis (RA) in Mexicans. HLA-DR and polymorphisms at positions -238 and -308 of TNF-alpha gene were determined in 137 Mexican RA patients (44 with severe and 93 with non-severe RA) as well as in 169 healthy controls (99 were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15725578
DOI: 10.1016/j.jaut.2004.11.002

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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