Article
Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with spondyloarthritis.
Human immunology - 1 Oct 2006
Vargas-Alarcón Gilberto, Casasola-Vargas Julio, Rodríguez-Pérez José Manuel, Huerta-Sil Gabriela, Pérez-Hernández Nonanzit, Londoño John, Pacheco-Tena Cesar, Cardiel Mario H, Granados Julio, Burgos-Vargas Rubén
Abstract excerpt
To evaluate the role of tumor necrosis factor-alpha (TNF-alpha) gene as susceptibility marker for spondyloarthritis (SpA), two polymorphisms (-238 and -308 positions) were analyzed in 229 patients with SpA (113 with ankylosing spondylitis [AS], 92 with undifferentiated SpA [U-SpA], 24 with reactive arthritis), and 169 ethnically matched healthy control subjects. The HLA-B alleles were detected by PCR-SSP...
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