Article
Tumor necrosis factor promoter polymorphisms in patients with rheumatoid arthritis in Taiwan.
The Journal of rheumatology - 1 Aug 2001
Yen J H, Chen C J, Tsai W C, Lin C H, Ou T T, Wu C C, Liu H W
Abstract excerpt
OBJECTIVE: To investigate the association of tumor necrosis factor (TNF) promoter polymorphisms with rheumatoid arthritis (RA) in Taiwan. METHODS: TNF promoter polymorphisms at positions -238, -244, -308, -376, -857, and -863 were determined in 97 patients with RA and 97 healthy controls using the PCR-RFLP method. RESULTS: The phenotypic frequency of TNF-308A was significantly lower in patients with RA than in...
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