Article
Association of tumor necrosis factor alpha and its receptor polymorphisms with rheumatoid arthritis in female patients.
Cellular immunology - 1 Jan 2011
Hussein Yousri M, Mohamed Randa H, Pasha Heba F, El-Shahawy Eman E, Alzahrani Saad S
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic autoimmune disorder associated with altered expression of pro-inflammatory cytokines. We aim to elucidate the association between the -308G/A polymorphism of the TNF-α gene and 196M/R polymorphism in TNFRII gene and susceptibility and severity of RA. One hundred and seventy-two RA patients and one hundred and sixty controls were enrolled in the study. Polymorphisms (SNPs) at...
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