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Article

Association of tumor necrosis factor alpha and its receptor polymorphisms with rheumatoid arthritis in female patients.

Cellular immunology - 1 Jan 2011

Hussein Yousri M, Mohamed Randa H, Pasha Heba F, El-Shahawy Eman E, Alzahrani Saad S

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic autoimmune disorder associated with altered expression of pro-inflammatory cytokines. We aim to elucidate the association between the -308G/A polymorphism of the TNF-α gene and 196M/R polymorphism in TNFRII gene and susceptibility and severity of RA. One hundred and seventy-two RA patients and one hundred and sixty controls were enrolled in the study. Polymorphisms (SNPs) at...

Topics

Adult
Alleles
Analysis of Variance
Arthritis, Rheumatoid
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Middle Aged
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide

Receptors, Tumor Necrosis Factor, Type II

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 21777909
DOI: 10.1016/j.cellimm.2011.06.023

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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