Article
Cytokine effects of CD23 are mediated by an epitope distinct from the IgE binding site.
The EMBO journal - 1 Dec 1992
Mossalayi M D, Arock M, Delespesse G, Hofstetter H, Bettler B, Dalloul A H, Kilchherr E, Quaaz F, Debré P, Sarfati M
Abstract excerpt
Human CD23 and its soluble forms (sCD23) display various biological activities, in addition to their IgE binding function (IgE/BF). The IgE binding domain was recently mapped to residues between Cys163 and Cys282 but its involvement in IgE-independent, CD23 functions remains unknown. In order to clarify this point, a series of N-terminal, C-terminal and internal deletion mutants of CD23 or sCD23 were expressed in...
Topics
- Animals
- B-Lymphocytes
- Binding Sites
- CHO Cells
- Cell Differentiation
- Cells, Cultured
- Cricetinae
- Cytokines
- Epitopes
- Hematopoietic Stem Cells
- Humans