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Article

Vincristine-induced central neurotoxicity in a collie homozygous for the ABCB1Δ mutation.

The Journal of small animal practice - 1 Mar 2012

Krugman L, Bryan J N, Mealey K L, Chen A

Abstract excerpt

A six-year-old, neutered, female collie was presented to an oncology specialty service after developing tetraparesis and self-mutilation that progressively worsened while receiving chemotherapy for lymphoma. Neurologic examination revealed ataxia, paresis and diminished conscious proprioception in all limbs with entire spinal reflexes. Magnetic resonance imaging of the brain and spinal cord was normal....

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Source

Identifiers

PMID: 22122243
DOI: 10.1111/j.1748-5827.2011.01155.x

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Vincristine-induced central neurotoxicity in a collie homozygous for the ABCB1Δ mutation.PMID 22122243Read ↗

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ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristine.Semantic proximity Read ↗

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Breed is associated with the ABCB1-1Δ mutation in Australian dogs.Semantic proximity Read ↗

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