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Article

New aminocoumarin antibiotics from genetically engineered Streptomyces strains.

Current medicinal chemistry - 1 Jan 2005

Li S-M, Heide L

Abstract excerpt

The aminocoumarin antibiotics novobiocin, clorobiocin and coumermycin A(1) are produced by different Streptomyces strains and are potent inhibitors of DNA gyrase. The biosynthetic gene clusters of all three antibiotics have been cloned and sequenced, and the function of most genes contained therein has been elucidated. In the last years, a number of "unnatural" aminocoumarins could be generated using the genetic...

Topics

Animals
Anti-Bacterial Agents
Coumarins
Genetic Engineering
Methyltransferases
Mutation
Streptomyces

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15720250
DOI: 10.2174/0929867053363063

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New aminocoumarin antibiotics from genetically engineered Streptomyces strains.PMID 15720250Read ↗

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