Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CloQ, a prenyltransferase involved in clorobiocin biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003

Pojer Florence, Wemakor Emmanuel, Kammerer Bernd, Chen Huawei, Walsh Christopher T, Li Shu-Ming, Heide Lutz

Abstract excerpt

Ring A (3-dimethylallyl-4-hydroxybenzoic acid) is a structural moiety of the aminocoumarin antibiotics novobiocin and clorobiocin. In the present study, the prenyltransferase involved in the biosynthesis of this moiety was identified from the clorobiocin producer (Streptomyces roseochromogenes), overexpressed, and purified. It is a soluble, monomeric 35-kDa protein, encoded by the structural gene cloQ....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to Coumarins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Mass Spectrometry

Share to Models, Chemical

Share to Novobiocin

Share to Streptomyces

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 12618544
DOI: 10.1073/pnas.0337708100
PMCID: PMC151338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CloQ, a prenyltransferase involved in clorobiocin biosynthesis.PMID 12618544Read ↗

A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042.Semantic proximity Read ↗

CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin.Semantic proximity Read ↗

CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin.Semantic proximity Read ↗

New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN.Semantic proximity Read ↗

New aminocoumarin antibiotics from genetically engineered Streptomyces strains.Semantic proximity Read ↗

In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach.Semantic proximity Read ↗

Assembly and heterologous expression of the coumermycin A1 gene cluster and production of new derivatives by genetic engineering.Semantic proximity Read ↗

Metabolic engineering of aminocoumarins: inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host.Semantic proximity Read ↗

Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics.Semantic proximity Read ↗

Biological activities of novel gyrase inhibitors of the aminocoumarin class.Semantic proximity Read ↗

Identification of six important amino acid residues of MenA from Bacillus subtilis natto for enzyme activity and formation of menaquinone.Semantic proximity Read ↗

Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.