Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs.

doi:10.1016/s1074-5521(03)00051-6

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Article

Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs.

Chemistry & biology - 1 Mar 2003

Eustáquio Alessandra S, Gust Bertolt, Luft Thomas, Li Shu Ming, Chater Keith F, Heide Lutz

Abstract excerpt

Clorobiocin (clo) and novobiocin (nov) are potent inhibitors of bacterial DNA gyrase. The two substances differ in the substitution pattern at C-8' of the aminocoumarin ring, carrying a chlorine atom or a methyl group, respectively. By gene inactivation, clo-hal was identified as the gene of the halogenase responsible for the introduction of the chlorine atom of clorobiocin. Inactivation of cloZ did not affect...

Topics

Anti-Bacterial Agents
Methyltransferases
Mutation
Novobiocin
Oxidoreductases
Streptomyces
Structure-Activity Relationship

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Open in PubMed

Identifiers

PMID: 12670542
DOI: 10.1016/s1074-5521(03)00051-6

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