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Article

Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis.

Antimicrobial agents and chemotherapy - 1 Apr 2004

Galm Ute, Heller Stefanie, Shapiro Stuart, Page Malcolm, Li Shu-Ming, Heide Lutz

Abstract excerpt

Twenty-eight novel clorobiocin derivatives obtained from mutasynthesis experiments were investigated for their inhibitory activity towards Escherichia coli DNA gyrase and for their antibacterial activities towards clinically relevant gram-positive and gram-negative bacteria in comparison to novobiocin and clorobiocin. Clorobiocin was the most active compound both against E. coli DNA gyrase in vitro and against...

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Identifiers

PMID: 15047534
DOI: 10.1128/AAC.48.4.1307-1312.2004
PMCID: PMC375324

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