Article
Drug synthesis by genetically engineered microorganisms.
Bio/technology (Nature Publishing Company) - 1 Apr 1994
Hutchinson C R
Abstract excerpt
The interplay between chemical and biological approaches to drug discovery and development is increasing with the advent of combinatorial methods that accelerate the output of screening programs and the development of genetically modified microorganisms able to make new metabolites and larger amounts of known ones. Actinomycetes, the most prolific microbial source of known drugs, can produce new aromatic...
Topics
- Anti-Bacterial Agents
- Bacteria
- Drug Evaluation, Preclinical
- Genes, Bacterial
- Genetic Engineering
- Molecular Structure
- Mutation
- Sequence Homology, Nucleic Acid