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Article

Assembly and heterologous expression of the coumermycin A1 gene cluster and production of new derivatives by genetic engineering.

Chembiochem : a European journal of chemical biology - 3 Mar 2008

Wolpert Manuel, Heide Lutz, Kammerer Bernd, Gust Bertolt

Abstract excerpt

Many secondary metabolites of clinical importance have been isolated from different Streptomyces species. As most of the natural producers remain difficult to handle genetically, heterologous expression of an entire biosynthetic gene cluster in a well characterised host allows improved possibilities for modifications of the desired compound by manipulation of the biosynthetic genes. However, the large size of a...

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PMID: 18288655
DOI: 10.1002/cbic.200700483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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