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Article

In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach.

Chemistry & biology - 1 Feb 2004

Galm Ute, Dessoy Marco Aurélio, Schmidt Jürgen, Wessjohann Ludger A, Heide Lutz

Abstract excerpt

The aminocoumarin antibiotics clorobiocin, novobiocin, and coumermycin A(1) are inhibitors of bacterial gyrase. Their chemical structures contain amide bonds, formed between an aminocoumarin ring and an aromatic acyl component, which is 3-dimethylallyl-4-hydroxybenzoate in the case of novobiocin and clorobiocin. These amide bonds are formed under catalysis of the gene products of cloL, novL, and couL,...

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Identifiers

PMID: 15123279
DOI: 10.1016/j.chembiol.2004.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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