Article
The interleukin-10 (-1082A/G) polymorphism is strongly associated with increased risk for oral squamous cell carcinoma.
Anticancer research - 1 Jan 2000
Vairaktaris Eleftherios, Yapijakis Christos, Serefoglou Zoe, Derka Spyridoula, Vassiliou Stavros, Nkenke Emeka, Vylliotis Antonis, Spyridonidou Sofia, Neukam Friedrich W, Schlegel Karl A, Patsouris Efstratios
Abstract excerpt
BACKGROUND: Increased levels of interleukin-10 (IL-10) have been observed in patients with oral cancer, possibly as a result of suppression of the immune response. Based on this, the -1082A/G polymorphism, which influences IL-10 gene expression level, was investigated in regard to its possible association with risk for oral cancer. PATIENTS AND METHODS: The polymorphism was examined in DNA samples of 144 patients...
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