Article
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).
Blood - 15 Jun 2005
De Keersmaecker Kim, Graux Carlos, Odero Maria D, Mentens Nicole, Somers Riet, Maertens Johan, Wlodarska Iwona, Vandenberghe Peter, Hagemeijer Anne, Marynen Peter, Cools Jan
Abstract excerpt
The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is rare in T-cell acute lymphoblastic leukemia (T-ALL). We recently identified NUP214-ABL1 as a variant ABL1 fusion gene in 6% of T-ALL patients. Here we describe the identification of another ABL1 fusion, EML1-ABL1, in a T-ALL patient with a cryptic t(9;14)(q34;q32) associated with...
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