Back to search

Article

A novel RUNX1::ABL1 transcript in B-cell acute lymphoblastic leukemia: a case report

2023-11-07

Abstract excerpt

Chromosomal translocations involving RUNX1 or ABL1 are frequently observed in haematologic neoplasms. Here, we describe a novel fusion between RUNX1 and ABL1 identified by mRNA sequencing in a recurrent case of B-cell acute lymphoblastic leukemia (B-ALL). Four in-frame transcripts were found, and the cells exhibited a BCR-ABL1 + ALL-like gene expression profile. The patient was a 12-year-old boy carrying a co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
91ffe2c1-75df-5f79-b568-e33de68dc865
DOI
10.22541/au.169933869.98014321/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A novel RUNX1::ABL1 transcript in B-cell acute lymphoblastic leukemia: a case reportDOI 10.22541/au.169933869.98014321/v1
Identification of Novel Fusion Genes in Pediatric B-ALL patients Using Whole Transcriptome SequencingSemantic proximity
Identification of Novel Fusion Genes in Pediatric B-ALL patients Using Whole Transcriptome SequencingSemantic proximity
BCR-ABL1-like B-Acute Lymphoblastic Leukemia/Lymphoma: A Comprehensive Review.Semantic proximity
Role of AML1/Runx1 in the pathogenesis of hematological malignanciesSemantic proximity
A rare e13a3 (b2a3) BCR-ABL1 fusion transcript with normal karyotype in chronic myeloid leukemia: The challenges in diagnosis and monitoring minimal residual disease (MRD)Semantic proximity
<i>ABL1</i> fusion genes in hematological malignancies: a reviewSemantic proximity
Genetic Profile, Treatment Response, and Outcomes of BCR::ABL1-Positive Mixed-Phenotype Acute Leukemia: A Study From the BCR::ABL1 Pathology Group.Semantic proximity
A novel BCR-ABL1 fusion gene identified by next-generation sequencing in chronic myeloid leukemiaSemantic proximity
Clinico-pathologic characteristics and outcomes of the World Health Organization (WHO) provisional entity de novo acute myeloid leukemia with mutated RUNX1.Semantic proximity
BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features.Semantic proximity
BCR/ABL1-Like Acute Lymphoblastic Leukemia: From Diagnostic Approaches to Molecularly Targeted Therapy.Semantic proximity
TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemiaSemantic proximity
Select a neighboring publication to make it the new centre.