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Clinico-biological features of T-cell acute lymphoblastic leukemia with fusion proteins

26 Jan 2022

Abstract excerpt

T-cell acute lymphoblastic leukemias (T-ALL) represent 15% of pediatric and 25% of adult ALL. Since they have a particularly poor outcome in relapsed/refractory cases, identifying prognosis factors at diagnosis is crucial to adapting treatment for high-risk patients. Unlike acute myeloid leukemia and BCP ALL, chromosomal rearrangements leading to chimeric fusion-proteins with strong prognosis impact are sparsely...

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PMID: 35082269
DOI: 10.1038/s41408-022-00613-9

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