Article
Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia.
Oncotarget - 17 Jan 2017
Boer Judith M, Steeghs Elisabeth M P, Marchante João R M, Boeree Aurélie, Beaudoin James J, Beverloo H Berna, Kuiper Roland P, Escherich Gabriele, van der Velden Vincent H J, van der Schoot C Ellen, de Groot-Kruseman Hester A, Pieters Rob, den Boer Monique L
Abstract excerpt
Approximately 15% of pediatric B cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by gene expression similar to that of BCR-ABL1-positive disease and unfavorable prognosis. This BCR-ABL1-like subtype shows a high frequency of B-cell development gene aberrations and tyrosine kinase-activating lesions. To evaluate the clinical significance of tyrosine kinase gene fusions in children with...
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