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Article

<i>ABL1</i> fusion genes in hematological malignancies: a review

15 Feb 2011

Abstract excerpt

Chromosomal rearrangements involving the ABL1 gene, leading to a BCR-ABL1 fusion gene, have been mainly associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia (ALL). At present, six other genes have been shown to fuse to ABL1. The kinase domain of ABL1 is retained in all chimeric proteins that are also composed of the N-terminal part of the partner protein that often includes a...

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PMID: 21435002
DOI: 10.1111/j.1600-0609.2011.01586.x

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