Article
Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1.
Tissue antigens - 1 Feb 2005
Ryan A W, Thornton J M, Brophy K, Daly J S, McLoughlin R M, O'Morain C, Abuzakouk M, Kennedy N P, Stevens F M, Feighery C, Kelleher D, McManus R
Abstract excerpt
Genetic predisposition to coeliac disease (CD) is determined primarily by alleles at the HLA-DQB locus, and evidence exists implicating other major histocompatibility complex-linked genes (6p21) and the CTLA4 locus on chromosome 2q33. In addition, extensive family studies have provided strong, reproducible evidence for a susceptibility locus on chromosome 5q (CELIAC2). However, the gene responsible has not been...
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