Article
Analysis of candidate genes on chromosomes 5q and 19p in celiac disease.
Journal of pediatric gastroenterology and nutrition - 1 Aug 2007
Latiano Anna, Mora Barbara, Bonamico Margherita, Megiorni Francesca, Mazzilli Maria Cristina, Cucchiara Salvatore, Palmieri Orazio, Valvano Maria Rosa, Annese Vito
Abstract excerpt
BACKGROUND AND AIM: Celiac disease (CD) is a multifactorial disease with involvement of both environmental and genetic susceptibility factors. The HLA-DQ loci account for <40% of CD heritability, but linkage studies have delineated other loci at the 5q31-33 (CELIAC2), and 19p13 regions (CELIAC4), similarly as in inflammatory bowel diseases. However, data in association studies are contradictory. To evaluate...
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