Article
A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhood.
International archives of allergy and immunology - 1 Dec 2004
Woitsch Bernd, Carr David, Stachel Daniel, Schmid Irene, Weiland Stephan K, Fritzsch Christian, von Mutius Erika, Kabesch Michael
Abstract excerpt
BACKGROUND: The interleukin (IL) 4/IL13 pathway is involved in the regulation of IgE production associated with atopic diseases. Numerous polymorphisms have been identified in the coding region of the IL4 receptor alpha chain (IL4Ra) and previous association studies have shown conflicting results...
Topics
- Asthma
- Child
- DNA
- Germany
- Haplotypes
- Humans
- Immunoglobulin E
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Receptors, Interleukin-4
- Sequence Analysis, DNA
- Skin Tests