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Article

Association of UGT1A1 polymorphism with prevalence and age at onset of cholelithiasis in sickle cell anemia.

Haematologica - 1 Feb 2005

Chaar Vicky, Kéclard Lysiane, Diara Jean Pierre, Leturdu Claudine, Elion Jacques, Krishnamoorthy Rajagopal, Clayton John, Romana Marc

Abstract excerpt

BACKGROUND AND OBJECTIVES: High levels of erythrocyte destruction in sickle cell anemia (SCA) result in chronic hyperbilirubinemia, with cholelithiasis occurring in a subset of patients. We investigated whether susceptibility to cholelithiasis in SCA was associated with the promoter polymorphism of the 5?-diphosphate-glucuronosyltransferase 1A1 (UGT1A1) gene encoding a key enzyme in bilirubin catabolism. DESIGN...

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PMID: 15710570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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